I fish SoHo a lot.. you can go all the way up to the wiers and fish off of them--I usually always catch something there... although on the weekends it gets packed. you can walk down river from there a long ways too or fish back behind the wiers in the still water.
you can also go off big springs as someone else mentioned, there are _huge_ fish on big springs but i've never had much luck there.. really picky fish.
Eddies fly shop is on your way if you go through johnson city to get there www.flyshopoftn.com
. they're excellent.
flies.. when the sulphurs are coming off the CDC comparidun is awesome (size 16 i think is what i normally use)
I caught a ~20 in brown on a cdc at the wiers a couple weeks ago.