Welcome to the board
Welcome to the board,
I often wondered about fly fishing in Missouri. Staying in Townsend is a great location you best bet for advice and flies is Little River Outfitters in Townsend you can't miss them, and of course there great message board.
At the moment all streams are fishing well lower streams are getting warm so moving up in elevation will help.
Good luck and hope you have a great vacation here in East TN.