I second the streamers.
Situation: You fished the micro-midge, Copper John, Prince, EHC until your arms are falling off. You've caught some fish but nothing that knocked your hat in the creek.
Tie on a Bright Wooly, or Olive with some flash, or one of my favorites a Grey Ghost. Cast to the areas (as mentioned before) that are ignored for the most part. Strip the fly aggressively with occasional long pauses. I have seen browns travel great distances (that make your heart skip a beat) to come get one of these offerings!
Hint: I always use a fairly heavy streamer. Seems I get strikes when the streamer is settling toward the bottom on the pauses.
"even Jesus had a 12 man recon team"