Just take it slow and be sure to carry a pack that carries well, be careful of the weight you carry try to get under 40lbs and wear comfortable shoes/boots I carry 32lbs with food for 2 days and all of my fly fishing gear including waders,vest and wading boots.
It is really nice to be the only one on the stream can be a bit scary too being in the middle of what seems like no where be sure to tell someone when you are expected back and where you are planning on being.
I am hitting Bryson Place on Deep Creek this weekend I'll let you know how many fisherman I see up there. I go for 2 days that way one can be spent hiking and setting up camp and the next one fishing all day then hike out the next. campsite #24 can be hiked and fished all in the same day very easy hike but also a popular area for that reason.