That's a long way to go for a Thursday-Sunday trip.
There's some good info on the Telluride Outside website: http://www.tellurideoutside.com/index.cfm?fuseaction=standard&categoryId=7&subCate goryId=0
I believe that Charlie's been to TellurideAnglers and has said they are friendly folks (much more so than Duranglers), you should probably stop in and pick their brains (and buy some flies, etc...)
In addition to the San Miguel, you are about 20 miles north of some of the upper tribs of the Dolores River. You might want to look into those, as well...